Polygenic prediction of the phenome, across ancestry, in emerging adulthood
نویسندگان
چکیده
منابع مشابه
Genetic risk for schizophrenia influences substance use in emerging adulthood: an event-level polygenic prediction model
Emerging adulthood is a peak period of risk for alcohol and illicit drug use. As genetic risk for schizophrenia has been previously associated with substance use disorders, we examine how schizophrenia-associated genetic variants are related to trajectories of five substance use behaviors as they occurred in daily life across emerging adulthood. Non-Hispanic European participants provided DNA s...
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BACKGROUND Heavy episodic drinking is developmentally normative among adolescents and young adults, but is linked to adverse consequences in later life, such as drug and alcohol dependence. Genetic and peer influences are robust predictors of heavy episodic drinking in youth, but little is known about the interplay between polygenic risk and peer influences as they impact developmental patterns...
متن کاملEmerging Adulthood and Its Characteristics in Iranian University Students
Purpose: Emerging adulthood (EA) theory has been proposed as a distinct developmental period between adolescence and adulthood by Arnett in 2000. This construct is promptly embraced by contemporary scholars, and research on emerging adulthood increased over the past decade in many countries, but yet questions remained about the universality of emerging adulthood. This article is extracted from ...
متن کاملTrajectories of binge drinking and personality change across emerging adulthood.
College students binge drink more frequently than the broader population, yet most individuals "mature out" of binge drinking. Impulsivity and sensation seeking traits are important for understanding who is at risk for maintaining binge drinking across college and the transition to adult roles. We use latent class growth analysis (LCGA) to examine longitudinal binge-drinking trajectories spanni...
متن کاملExplicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction.
Polygenic prediction using genome-wide SNPs can provide high prediction accuracy for complex traits. Here, we investigate the question of how to account for genetic ancestry when conducting polygenic prediction. We show that the accuracy of polygenic prediction in structured populations may be partly due to genetic ancestry. However, we hypothesized that explicitly modeling ancestry could impro...
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ژورنال
عنوان ژورنال: Psychological Medicine
سال: 2017
ISSN: 0033-2917,1469-8978
DOI: 10.1017/s0033291717003312